Table 1. Summary of tested extracts/fractions.
| Fraction | Concentr- | Extract effect on cell activity (hFOBs, MSCs) | ||||
|---|---|---|---|---|---|---|
| number | Common name | Genera/Species/description | ation (μg/ml) | Cytotoxicity | Proliferation | Differentiation |
| DMSO dissolved extracts | ||||||
| D-01 | Red algae | Bonnemaisonia hamifera | 5.83 | Non-toxic | Small decrease | None |
| D-02 | Coastal sponge | Porifera demospongiae | 5.97 | Non-toxic | None | |
| D-03 | Brown algae | Bifurcaria bifurcata | 5.82 | Non-toxic | None | |
| D-04 | Coastal sponge | Porifera; Order Poecilosclerida | 6.34 | Non-toxic | None | |
| D-05(1) | Coastal sea squirt | Chordata; Class Ascidiacea | 5.80 | Non-toxic | None | |
| D-06 | Coastal sponge | Halichondria panicea | 5.87 | Non-toxic | None | |
| D-07 | Red algae | Anotrichium barbatum | 5.71 | Non-toxic | None | |
| D-08 | Star fish | Asterias rubens | 6.00 | Non-toxic | None | None |
| D-09(2) | Coastal sea squirt | Chordata; Class Ascidiacea | 5.66 | Non-toxic | Small decrease | Small decrease |
| D-10 | Coastal sponge | Haliclona indistincta | 5.76 | Non-toxic | None | |
| D-11 | Red algae | Griffithsia corallinoides | 5.84 | Non-toxic | None | |
| D-12 | Red algae | Bonnemaisonia hamifera | 6.12 | Non-toxic | None | |
| D-13 | Coastal sponge | Porifera; Order Poecilosclerida | 6.16 | Non-toxic | None | |
| D-14 | Coastal sponge | Dictyoceratid sponge | 5.80 | Non-toxic | None | |
| D-15 | Green algae | Ulva linza | 5.76 | Decreased | None | Small increase |
| D-16 | Brown algae | Cystoseira tamariscifolia | 5.80 | Decreased | None | |
| D-17 | Red algae | Polysiphonia elongata | 6.12 | Decreased | Small decrease | None |
| D-18 | Brown algae | Sargassum muticum | 6.11 | Decreased | None | |
| D-19 | Coastal sponge | Porifera; Family Suberitidae | 5.96 | Decreased | None | |
| D-20 | Brown algae | Desmarestia aculeata | 5.90 | Decreased | Small decrease | Increased |
| D-21 | Red algae | Polysiphonia stricta | 5.72 | Decreased | Small decrease | Decreased |
| D-22 | Coastal sponge | Polymastia boletiformis | 5.98 | Decreased | None | |
| D-23 | Brown algae | Sargassum muticum | 5.85 | Decreased | None | |
| D-24 | Coastal sponge | Suberites ficus | 6.03 | Decreased | Small decrease | Decreased |
| D-25 | Coastal sponge | Dysidea fragilis | 5.91 | Decreased | None | None |
| D-26(1) | Tunicate | Ascidian; Family Styelidae | 6.03 | Decreased | None | Increased |
| D-27 | Coastal sponge | Haliclona simulans | 6.04 | Decreased | Small decrease | None |
| D-28(2) | Tunicate | Ascidian; Family Styelidae | 5.84 | Decreased | Small decrease | None |
| D-29 | Coastal sponge | Haliclona indistincta | 6.23 | Decreased | Small increase | |
| D-30 | Brown algae | Cystoseira baccata | 5.70 | Decreased | Small increase | |
| D-31 | Brown algae | Desmarestia viridis | 6.06 | Decreased | None | |
| D-32 | Brown algae | Desmarestia ligulata | 6.25 | Decreased | Small increase | None |
| D-33 | Coral | Soft coral | 5.36 | Decreased | Small increase | None |
| D-34 | Hydrozoan | Hydrozoan | 4.00 | Decreased | None | None |
| D-35 | Coastal sponge | Sea fan; Paramuricea | 6.06 | Decreased | None | |
| D-36 | Sea star | Sea star | 6.07 | Decreased | Small increase | None |
| D-37 | Brittle star | N/A | 5.33 | Decreased | Small increase | None |
| D-38 | Brown algae | Cystoseira foeniculacea | 6.20 | Decreased | Small increase | |
| D-39 | Brown algae | Cystoseira nodicaulis | 6.04 | Decreased | None | None |
| D-40 | Deep sea sponge | Lissodendoryx diversichela | 5.67 | Decreased | None | None |
| D-41 | Sea cucumber | N/A | 6.00 | Decreased | None | |
| D-42 | Sea fan | N/A | 6.00 | Decreased | None | |
| Ethanol dissolved extracts | ||||||
| E-01 | Star fish | N/A | 150 | Small increase | Decreased | Decreased |
| E-02 | Sea fan | N/A | 150 | Non-toxic | None | |
| E-03 | Deep sea sponge | Haliclona simulans | 150 | Non-toxic | None | |
| E-04 | Soft coral | Soft coral | 150 | Increase | Decrease | Decreased |
| E-05 | Sea star | Sea star | 150 | Non-toxic | None | Small increase |
| E-06 | Sea star | Cushion star fish | 150 | Non-toxic | Decreased | |
| E-07 | Sea star | N/A | 150 | Non-toxic | None | |
| E-08 | Sea star | Sea star | 150 | Non-toxic | Decreased | |
| E-09 | Sea pen | Sea pen | 150 | Non-toxic | None | |
| E-10 | Sea star | Cushion sea star | 150 | Non-toxic | None | |
| E-11 | Sea fan | Phanophathes sp. | 150 | Non-toxic | None | Decreased |
| E-12 | Red algae | Corallina elongata | 150 | Non-toxic | None | |
| E-13 | Algae (griffithsia) | Griffithsia corallinoides | 150 | Non-toxic | None | |
| E-14 | Sea star | Cushion sea star | 150 | increase | None | |
| E-15 | Sea fan | Pentaculacea | 150 | Non-toxic | None | |
| E-16 | Deep sea sponge | Haliclona indistincta | 150 | Non-toxic | Decreased | |
| E-17 | Red algae | Ceramium secundatum | 150 | Non-toxic | Decreased | Decreased |
| E-18 | Brown algae | Bifurcaria bifurcata | 150 | Toxic | Decreased | |
| E-19 | Red algae | Boergeseniella fructiculosa | 20.8 | Non-toxic | Decreased | None |
| E-20 | Red algae | Plocamium cartilagineum | 150 | Increase | Decreased | Decreased |
| E-21 | Red algae | Osmundea sp. | 150 | Decreased | None | Decreased |
| E-22 | Brown algae | Ectocarpales (Puncatria) | 86 | Decreased | None | Decreased |
| E-23 | Sponge | Cladostephus spongiosus | 150 | Non-toxic | Decreased | |
| E-24 | Coral | N/A | 150 | Non-toxic | Decreased | Decreased |
| E-25 | Deep sea sponge | Haliclona indistincta | 150 | Decreased | None | Decreased |
| Powder residue extracts | ||||||
| P-01 | Coral | Lophelia coral | 1 small decrease | None | ||
| P-02 | Seaweed | Percursaria percursa | 1 small decrease | Increased | ||
| P-03 | Red algae | Porphyra umbilicalis | 1 small decrease | Small decrease | ||
| P-04 | Deep sea sponge | Psolus squamatus | 1 small decrease | Increased | ||
| P-05 | Red algae | Osmundea sp. | 1 small decrease | Decreased | ||
| P-06 | Red algae | Ceramium pallidum | Variable | Increased | ||
‘D’ indicates a fraction/extract dissolved in DMSO, ‘E’ indicates dissolved in ethanol and ‘P’ indicates a powder residue. (1) and (2) indicate separate samples from the same species.