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. 2018 Nov 28;13(11):e0207374. doi: 10.1371/journal.pone.0207374

Fig 6. Inflammatory signaling GO terms and pathways are overrepresented by genes upregulated in RORA deletion cells.

Fig 6

A. Top 20 Biological Process GO terms enriched among differentially expressed genes describe inflammatory signaling mediated processes. B. Similar overrepresentation of inflammation related functions was found among the Top 20 Molecular Function GO terms. The ratio of identified differentially expressed genes to the total number of genes within each term is shown on the x-axis. C. Top 10 KEGG pathways enriched by genes upregulated in the RORA knockout cells are all involved in mediating inflammatory signaling. D. Barcode plot illustrating overrepresentation of upregulated (21 out of 24) differentially expressed genes in of the Cytokine-cytokine receptor interaction pathway. Only 3 downregulated genes were represented in this pathway.