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mPTP opening in brain cortex at 6 h after CA/CPR. n = 4 in each group. *P < 0.001 versus Naïve. #P < 0.05 versus Vehicle. Naïve = untreated naïve mice. Vehicle = mice treated with vehicle 2 min before CPR. AP39 = mice treated with AP39 at 1000 nmol kg−1 2 min before CPR.