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. 2018 Oct 2;33(11):1688–1699. doi: 10.1002/mds.102

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© 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Voxel‐based analysis of longitudinal changes in regional metabolic activity. Metabolic increases with disease progression are displayed using a warm colors. Progressive metabolic declines are displayed using a cold colors. (B) metabolic data at each timepoint. The coordinates refer to the Montreal Neurological Institute (MNI) standard space. GPi, internal globus pallidus; STN, subthalamic nucleus; BA, Brodmann area. Figure reprinted with permission from Huang C, Tang C, Feigin A, et al. Changes in network activity with the progression of Parkinson's disease. Brain 2007;130(7):1834‐1846.120