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Combined treatment of PFK158 and chemotherapeutic agents enhances cell death. AnnexinV/Propidium Iodide (PI) staining of OV2008 (a), C13 (b), HeyA8 (c) and HeyA8MDR (d) cells treated with PFK158 and/or cotreated with CBPt or PTX for 24 h shows that the combination of PFK158 with chemotherapeutic agents was more effective in inducing cell death in the resistant cells. Data are representative of three independent experiments where *P < 0.001.
