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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Hum Hered. 2018 Jun 5;83(2):65–70. doi: 10.1159/000488942

Figure 1. Weak overlap between germline genetic variants in three lung cancer subtypes.

Figure 1

Panel A shows the overlap between single nucleotide polymorphisms (SNPs) at p < 1 × 10−5 from McKay et al. Panel B shows the overlap between subtypes by the cytobands represented by the SNPs in Panel A. The full set of SNPs trimmed by linkage disequilibrium (LD) (r2 > 0.8, 1000 Genomes Phase III) reveals few genomic regions shared by all three lung cancer subtypes in Panel C. To account for the strong LD in the MHC region, we represent all SNPs in MHC as one genomic loci in the LD trim and show the final overlapping independent genomic regions in Panel D. Of note, the 24 independent regions represented in Panel D are from two chromosomes: chromosome 6 and chromosome 15.