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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Exp Neurol. 2018 Sep 12;311:1–14. doi: 10.1016/j.expneurol.2018.09.007

Fig. 2. Immunohistochemical double staining of HMGB1 with a neuronal marker NeuN in the neonatal rat cerebral cortex at zero, 3, 6, 12, 24, and 48 h after exposure to HI injury.

Fig. 2

HMGB1 translocation was observed as early as zero and 3 h after HI injury (zero and 3 h, yellow arrows). HMGB1 release was detected at 6 h after HI injury (6 h, thick white arrows). Major release of HMGB1 into extracellular compartment was observed at 48 h after HI injury (48 h, thick white arrows). Scale bar = 20 μm.