Fig. 6.

(a) The structure of Mem-RhoNox. (b) Schematic diagram of the mechanism by which Mem-RhoNox detects transferrin (Tf)-delivered Fe(II) ions. (c) Time-lapse fluorescence imaging of the Tf-triggered release of Fe(II) ions in HepG2 cells that were stained with Mem-RhoNox. Bar = 10 μm. (d) Time-lapse fluorescence images of the Tf-triggered release of Fe(II) ions in primary-cultured mouse neurons that were stained with Mem-RhoNox and green fluorescent protein (GFP). The neurons were visualized using an overlapped image of GFP and differential interference contrast (DIC) (left). Bars = 10 μm.