Table 1.

Types of Prion disease in both human and animals

Types of disease	Types of host	Pathogenesis
Kuru	Humans	Infection through ritualistic cannibalism
Iatrogenic Creutzfeldt–Jakob disease	Humans	Infection from prion-contaminated HGH, medical equipment, etc.
Variant Creutzfeldt–Jakob disease	Humans	Infection from bovine prions
Familial Creutzfeldt–Jakob disease	Humans	Germline mutations in the PRNP gene
Gerstmann–Sträussler–Scheinker syndrome	Humans	Germline mutations in the PRNP gene
Fatal familial insomnia	Humans	Germline mutations in the PRNP gene
Sporadic Creutzfeldt–Jakob disease	Humans	Somatic mutation or spontaneous conversion of PrPc to PrPsc
Sporadic Fatal insomnia	Humans	Somatic mutation or spontaneous conversion of PrPc to PrPsc
Scrapie	Sheep	Infection
Bovine spongiform encephalopathy	Cattle	Infection or sporadic
Transmissible mink encephalopathy	Mink	Infection with prions from sheep or cattle
Chronic wasting disease	Deer, elk	Infection
Feline spongiform encephalopathy	Cats	Infection with prion-contaminated bovine tissues or MBM
Exotic ungulate encephalopathy	Greater kudu, nyala, oryx	Infection with prion-contaminated MBM