Fig. 3.

The role of plant compounds in the chemical modification of histones. Phytochemicals affect the functions of KMTs, KDMs, HDACs, HATs, and DNMTs and thus regulate genes’ transcription activity. SWI/SNF (SWItch/Sucrose Non-Fermentable), is ATP-dependent nucleosome remodeling protein complex. It is able to restructure the nucleosome to make its DNA accessible during transcription, replication, and DNA repair. DNMTs, DNA methyltransferases; HATs, histone acetyltransferases; HDACs, histone deacetylases; KDMs, lysine demethylases; KMTs, lysine methyltransferases