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. 2018 Nov 22;9:1343. doi: 10.3389/fphar.2018.01343

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Copyright © 2018 Ye, Duan, Deng, Wang, Chen, Cui, Sun, Zhang, Du, Gu, Lin and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DENND1A binds to the SH3 domain of Grb2 through PRD. (A) Schematic diagram of different Flag-tagged Grb2 fragments and HA-tagged DENND1A fragments. (B) Coprecipitation of HA-tagged DENND1A fragments or (C) Flag-tagged Grb2 fragments with Flag-Grb2 or HA-DENND1A were analyzed by immunoblotting. Unprocessed lysates of HEK-293T cells transfected with Flag-Grb2 or HA-DENND1A was used as input. All experiments were repeated at least three times.