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. 2018 Nov 28;8:17447. doi: 10.1038/s41598-018-35593-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CLIP-170 phosphorylation up-regulates microtubule plus-end dynamics, but T cell stimulation does not. (a–c) TIRF live-cell images (top) and kymographs (bottom) of CLIP-170 comets and microtubule plus-end dynamics visualised using C-terminal mEGFP-tagged CLIP-170s: wild-type in stimulated cells (a), S312A mutant in stimulated cells (b), and wild-type in unstimulated cells (c) (see Movie S1). (d,e) The velocity (d) and the length (e) of CLIP-170 comets, quantified using the images. Bars in TIRF images, 5 μm; horizontal and vertical bars in kymographs, 1.5 μm and 20 s, respectively. Data are means ± SD. Source data, Table S4.