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. 2018 Nov 28;9:5031. doi: 10.1038/s41467-018-07478-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — NRGF-HIS/Flt3LG mice display an extensive transcriptomic signature. a Schematic representation of the experimental procedure to characterize the PBMC transcriptomic signature of NRGF-HIS mice following YFV-17D infection. b Number of significantly DE genes (p_adj ≤ 0.05) at day 11 post YFV-17D infection (versus day 0, prior infection) in the PBMCs of NRG-HIS (red), NRGF-HIS/Fluc (green), and NRGF-HIS/Flt3LG (blue) mouse PBMCs upon YFV-17D infection. c Protein–protein network of significantly DE (p_adj ≤ 0.05) in NRGF-HIS mice following YFV-17D infection. Each gene is colored based on its log₂FC (1 < x < 2, red; 0.5 < x < 1, orange; −1 < x < −0.5, yellow; −2 < x < −1, green). Areas enriched with genes related to a specific biological process are highlighted by a dotted circle or ellipse. d Frequencies of upregulated (red area) or downregulated (blue area) immune-related GO terms among all statistically significant GO terms (p ≤ 0.05) in NRG-HIS (red), NRGF-HIS/Fluc (green), and NRGF-HIS/Flt3LG (blue) mice following replicate analysis. Total count of immune-related GO-terms out of all significant GO terms (displayed as immune-related/all) are also reported. Dotted lines between the bars symbolize the progressive enhancement of human immune functionality across our humanized mice models. e KEGG pathway enrichment analysis of the transcriptomes of NRG-HIS (red), NRGF-HIS/Fluc (green), and NRGF-HIS/Flt3LG (blue) mouse PBMCs following replicate analysis. For each experimental setting or mouse model, the top five upregulated KEGG pathways are listed (q value ≤ 0.06)