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. 2018 Nov 28;9:5031. doi: 10.1038/s41467-018-07478-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Human-like transcriptomic response to YFV-17D infection in NRGF-HIS/Flt3LG. Differentially expressed genes from PBMCs of three YFV-17D human vaccinee cohorts (Lausanne, n = 11; Montreal, n = 15; Emory, n = 25) were used to generate two global human transcriptomic datasets: an unbiased dataset (all differentially expressed genes (p_adj ≤ 0.1) found in at least one cohort) and an double-selection dataset (all differentially expressed genes (p_adj ≤ 0.1) found in at least two cohorts). For a given human global dataset (unbiased, left; double selection, right) and p_adj threshold (starting at p_adj ≤ 0.1 with 0.01 increment), the Spearman rho correlation index was computed for each humanized mouse model transcriptomic dataset (NRG-HIS, NRGF-HIS/Fluc, and NRGF-HIS/Flt3LG) and plotted as function of the p_adj threshold. The Spearman rho correlation index for the unbiased and double selection method are respectively referred as r_U and r_D. The definitive correlation indexes for the unbiased and double selection method, referred as r_U and r_D at p_adj = 0.05 (r_U,q=0.05 and r_D,q=0.05) respectively, are indicated on each graph and for each humanized mouse model. See Methods for more details