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. 2018 Nov 28;9:5044. doi: 10.1038/s41467-018-07197-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Therapeutic effects of the bio-NRs in vivo. a Schematic illustration of the in vivo therapeutic process. b Macroscopic images of lungs receiving different treatments. From left to right: control, HMSNs-GOx@CPPO-PFC/O₂@C, HMSNs-Ce6@CPPO-PFC/O₂@C, HMSNs-GOx-Ce6@CPPO-PFC@C, and HMSNs-GOx-Ce6@CPPO-PFC/O₂@C. c The mass percentage of metastases. Mass percentage of metastases/% = weight of metastatic tumors/weight of normal lung. d Body weight curves of mice with metastatic tumors in each group. e Survival rates for each group after receiving treatments. f H&E staining of lung-bearing metastatic tumors after different treatments (×200, scale bars are 100 μm). T= tumor