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The domain architecture of the EspF protein. (A) EspF amino acid sequences and domain architecture diagrams of EPEC O127:H7 strain E2348/69, EHEC O157:H7 strain EDL933, and C. rodentium are shown. Differences in the size of their EspF proteins are caused by differences in the number of repeats of PRR in the C-terminal domain. (B) EHEC EspF protein C-terminal PRR repeats, including the SNX9 protein binding motif RxAPxxP, and the N-WASP protein binding sequence xHLAAYExSKxxxx.
