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A schematic model for how EspF potentially disrupts tight junctions. EspF interacts with CK18 and 14-3-3ζ to redistribute intermediate filaments and combines with N-WASP, Arp2/3, actin, profilin, and ZO-1 to recruit junctional proteins to the pedestal. This results in the redistribution of tight junction proteins, depolymerization of actin, and interruption of tight junctions.
