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. 2018 Nov 22;9:2738. doi: 10.3389/fimmu.2018.02738

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Copyright © 2018 Li and Leonard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription factors that mediate chromatin accessibility during early thymic T cell development. Multiple TFs play roles in early stages of T cell maturation, which involve commitment of hematopoietic stem cells to T cell progenitors. The early DN stage consists of DN1, DN2a/b, DN3a/b, and DN4 cells. During T cell commitment, which occurs between the DN2a and DN2b stages, TCF-1 establishes chromatin accessibility and mediates compartment switch, where repressive compartments that harbor T cell-lineage-specific genes (e.g., Bcl11b) are switched to transcriptionally active compartments. TCF-1 upregulates the expression of BCL11B, which further remodels chromatin architecture and stabilizes the intra-TAD contacts within mature T cell subsets.