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. 2018 Nov 22;12:858. doi: 10.3389/fnins.2018.00858

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Copyright © 2018 Guo, Feng, Wang and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Axonal responses during high-frequency stimulation (HFS) when the extracellular K⁺ concentration was fixed at 3 mM: (A) Action potentials induced by 130 Hz pulses during 2-s HFS. (B) Membrane potential at Node₁₁ (black curves) and [K⁺]_o in the peri-axonal space of neighboring JXP (blue curves) during the first and last 0.2 s of the 2-s HFS shown in (A). Every stimulation pulse induces an action potential.