Table 3.
Multivariable Adjusted Analysis for Risk of Increased in Carotid Intima Media Thickness
| Outcome | Parameter | (SE) | 95% CI of | P Value |
|---|---|---|---|---|
| Model 1a | ||||
| cIMT over 96 weeks (mm) | Baseline serum albumin (g/dL) | −0.05 (0.03) | (−0.106 to −0.0004) | .05 |
| Age (year) | 0.007 (0.001) | (0.005 to 0.009) | <.001 | |
| Sex (male vs female) | −0.04 (0.02) | (−0.08 to 0.01) | .14 | |
| Current smoking | −0.009 (0.012) | (−0.03 to 0.01) | .45 | |
| Body mass index (kg/m2) | −0.0006 (0.0013) | (−0.0032 to 0.0020) | .65 | |
| Creatinine clearance (mL/min) | 0.0001 (0.0002) | (−0.0002 to 0.0005) | .53 | |
| LDL cholesterol (mg/dL) | 0.00009 (0.00012) | (−0.00015 to 0.00033) | .45 | |
| Model 2b | ||||
| cIMT over 96 weeks (mm) | Baseline serum albumin (g/dL) | −0.05 (0.03) | (−0.110 to 0.003) | .06 |
| Age (year) | 0.0070 (0.0009) | (0.0052–0.0088) | <.001 | |
| Sex (male vs female) | −0.04 (0.02) | (−0.081 to 0.009) | .12 | |
| hsCRP (μg/mL) | −0.0006 (0.0007) | (−0.002 to 0.0008) | .42 | |
| Statin | −0.0002 (0.0001) | (−0.0005 to 0.00001) | .06 | |
| Model 3c | ||||
| cIMT over 96 weeks (mm) | Baseline serum albumin (g/dL) | −0.05 (0.03) | (−0.102 to 0.008) | .09 |
| Age (year) | 0.007 (0.0009) | (0.005 to 0.009) | <.001 | |
| Sex (male vs female) | −0.04 (0.02) | (−0.081 to 0.009) | .12 | |
| IL-6 (pg/mL) | 0.0005 (0.0004) | (−0.0002 to 0.0012) | .19 | |
| Statin | −0.0002 (0.0001) | (−0.00051 to 0.00002) | .07 | |
| Categorizing Baseline Albumin by 4 Quartilesd | ||||
| cIMT over 96 weeks (mm) | Albumin (low vs lower middle) | −0.05 (0.02) | (−0.11 to −0.01) | .02 |
| Albumin (low vs higher middle) | −0.07 (0.03) | (−0.13 to −0.01) | .02 | |
| Albumin (low vs high) | −0.05 (0.02) | (−0.096 to 0.001) | .06 | |
| Age (year) | 0.0068 (0.0009) | (0.005–0.009) | <.001 | |
| Sex (male vs female) | −0.04 (0.02) | (−0.083 to 0.005) | .08 | |
| IL-6 (pg/mL) | 0.0005 (0.0004) | (−0.0002 to 0.0011) | .20 | |
| Statin | −0.0003 (0.0001) | (−0.00051 to 0.00002) | .07 | |
Abbreviations: BMI, body mass index; CI, confidence interval; cIMT, carotid intima media thickness; hsCRP, high-sensitivity C-reactive protein; IL, interleukin; LDL, low-density lipoprotein.
aModel 1 regresses baseline serum albumin on IMT over 96 weeks, controlling for age, sex, current smoking, BMI, creatinine clearance, and LDL. Bolded values represent significant P values, P ≤ .05.
bModel 2 regresses baseline serum albumin on IMT over 96 weeks, controlling for age, sex, hsCRP, and statin use (randomization group) over the study period.
cModel 3 regresses baseline serum albumin on IMT over 96 weeks, controlling for age, sex, IL-6 and statin use (randomization group) over the study period.
dModel 4 regresses baseline serum albumin, as categorized by quartiles (<3.8 g/dL [low]; 3.8–4.1 g/dL [lower middle]; 4.1 g/d–4.3 g/dL [higher middle]; and >4.3 g/dL [high]), on IMT over 96 weeks, controlling for age, sex, IL-6, and statin use (randomization group) over the study period.