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. 2018 Nov 20;5:289. doi: 10.3389/fvets.2018.00289

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Copyright © 2018 Ichii, Ohta, Horino, Nakamura, Hosotani, Mizoguchi, Morishita, Nakamura, Sasaki, Takiguchi, Sato, Oyamada, Elewa and Kon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between miRNA parameters and renal function in cats. (A)The ratio of miR-21 to let-7b, miR-181a to let-7b, and miR-181a to miR-10b in urinary exosome-derived miRNA in cats. Cats were divided into the normal renal function group (NR, blood urea nitrogen (BUN) = 12.8–29.8 mg/dL, serum creatinine (sCRE) = 0.4–1.5 mg/dL, n = 43) and kidney disease group (KD, BUN = 30.1–140.0 mg/dL, sCRE = 1.8–14.0 mg/dL, n = 47). Furthermore, based on serum creatinine levels, the KD group was divided into three groups including KD1 (1.6–2.8 mg/dL), KD2 (2.9–5.0 mg/dL), and KD3 (5.0> mg/dL). Kruskal-Wallis test was used for comparing over three populations or time points, and multiple comparisons were performed using Dunnett's test when a significant difference was observed (^*, ^**, ^*** P < 0.05, 0.01, 0.001). TaqMan PCR method. Bars in graphs show the mean of each group. For each value, a receiver operating characteristic (ROC) curve was drawn. AUC, area under the curve; CV, cutoff value; Sp, specificity; Se, sensitivity. Objective variables were examined as 0 (NR) and 1 (KD). (B)Correlation between the ratio of miR-21 to let-7b and sCRE, BUN, and uCRE. Spearman's correlation test was used to analyze the correlation between the two parameters (^**P < 0.01). NR (blue, n = 43), KD1 (green, n = 19), KD2 (light blue, n = 18), and KD3 (red, n = 8) cats were analyzed. (C)The correlation between the ratio of miR-21 to let-7b and sCRE, BUN, and uCRE. Spearman's correlation test was used to analyze the correlation between two parameters (^*, ^** P < 0.05, P < 0.01). KD (45) cats were analyzed.