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. 2018 Nov 29;141(12):3428–3442. doi: 10.1093/brain/awy284

Figure 1.

Figure 1

Physiological expression of mutant CHMP2B results in a decrease of endolysosomes at the soma of cortical neurons. (A) Western blot of CHMP2B levels on brain homogenates from P0 or P1 postnatal mutant CHMP2B mice or non-transgenic controls. β-actin is shown as a loading control. Bracket indicates non-specific bands. (B) Quantification of bands shown in A relative to loading controls. (C) LAMP2 staining in mutant CHMP2B and control β-tubulin stained cortical neurons. Scale bar = 10 µm. (D) Quantification of LAMP2-positive structures in DIV 14–16 cortical neurons. n = 3, with 6–10 neurons per n. Unpaired t-test, **P < 0.01.