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. 2018 Nov 29;141(12):3428–3442. doi: 10.1093/brain/awy284

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© The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mutant CHMP2B does not recruit VPS4. (A) Representative examples of neurons co-transfected with haemagglutinin (HA) tagged CHMP2B and GFP-VPS4. Asterisk indicates an example of localization of mutant HA-CHMP2B, which is negative for VPS4. (B) Representative examples of neurons co-transfected with GFP-VPS4EQ and HA-tagged wild-type (top) or mutant CHMP2B (bottom). Arrowhead (top) indicates area of co-localization of wild-type CHMP2B with VPS4EQ. Arrows (bottom) show differential localization of mutant CHMP2B and VPS4EQ. DIV 8 cortical cultures. (C) Manders coefficient of co-localization generated using JaCoP in ImageJ. Unpaired t-test, *P < 0.05. Scale bars = 10 µm.