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Spinal cord p38 MAPK inhibition reduces joint cytokine production. Knee joint (a) TNF-α, (b) IL-1β and (c) MIP-2 levels were measured 1.5 h after zymosan injection (i.a.; 30 μg) in mice pretreated with SB203580 (i.t.; 3 μg) by ELISA. Data are expressed as the mean ± SEM (n = 4–8 mice/group). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. control group (zymosan). (One-way anova followed by Tukey’s post hoc test).
