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. Author manuscript; available in PMC: 2018 Nov 29.
Published in final edited form as: Fundam Clin Pharmacol. 2017 Dec 22;32(2):155–162. doi: 10.1111/fcp.12338

Figure 4.

Figure 4

The anti-inflammatory of spinal p38 MAPK inhibition is dependent on participation of sympathetic nervous system and beta-adrenergic receptors activation. (a) Guanethidine (s.c.; 50 mg/kg; −48 and −24 h) and (b) nadolol (s.c.; 5 mg/kg;−30 min) were previously administrated in mice injected with SB203580 (i.t.; 3 μg). Neutrophil recruitment was measured 6 h after zymosan injection (i.a.; 30 μg). Data are expressed as the mean ± SEM (n = 4–8 mice/group). **P < 0.01 and ***p < 0.001 vs. control group (zymosan). (One-way anova followed by Tukey’s post hoc test)