. 2018 Nov 28;24(44):4962–4973. doi: 10.3748/wjg.v24.i44.4962

Table 1.

Hepatitis C virus-derived mechanisms underlying dendritic cell impairment

HCV protein	Target cells	Functional change	Mechanism	Ref.
HCV core and NS3	mDCs	Impaired maturation	Increased IL-10 and decreased IL-12 production	[64]
HCV core and NS3	mDCs	Impaired T-cell stimulation	Increased IL-10 and decreased IL-12 production	[64]
E2	mDCs	Alter DC migratory behavior	Interacts with CD81	[120]
	pDCs	Inhibited maturation		[121]
		Impaired activation
		Decreased IFN-α production
E2 andNS3	mDCs	Impaired IFN-λ production	Not shown	[113]
NS4	mDCs	Th1 cytokine reduction	Not shown	[122]
NS4	mDCs	T-cell stimulatory impairment	Not shown	[122]
NS5A	mDCs	Increased IL-8 production	Not shown	[123]
NS5A	mDCs	Impaired interferon signaling	Influence the phosphorylation of STAT1 and STAT2	[123]

HCV: Hepatitis C virus; NS: Nonstructural protein; mDC: Myeloid dendritic cell; pDC: Plasmacytoid dendritic cell; IL: Interleukin; Th1: Type 1 help T cell; IFN: Interferon; STAT: Signal transducer and activator of transcription.