FIG 8.

Diagrammatic representation of the network controlling production of Vsm and PrtV in V. tasmaniensis. At least 5 overlapping but distinct pathways control production of PrtV and Vsm in V. tasmaniensis LGP32. The QS pathway is depicted in blue. The VarS/VarA-independent–CsrB1/CsrA-dependent pathway is depicted in gray. The VarS/VarA/CsrB2,3,4/CsrA-dependent pathway is depicted in golden yellow. A putative VarS/VarA-dependent pathway controlling hapR and rpoS expression through the activity of a putative positive X factor is depicted in red. Other signals contributing to rpoS expression are depicted in green. The combination of colors in symbols representing LuxO, HapR, σS, PrtV, and Vsm conceptually indicates the combined contributions of all of the pathways/signals to expression. Since we did not quantitatively determine their respective contributions in this study, this is not meant to be a quantitative representation. Positive actions are represented by arrowheads, whereas negative actions are depicted by solid ellipsoids. Solid lines indicate direct actions, whereas dashed lines indicate indirect actions and/or unknown mechanisms. Putative pathways are further indicated by question marks.