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. 2018 Sep 11;97(13):1416–1423. doi: 10.1177/0022034518798825

Table.

Male versus Female Inflammatory Polymerase Chain Reaction Array Summary from Isolated Neutrophils.

Treatment vs. Control
Gene ID Function Female Male
C5ar1 Neutrophil migration and recruitment 1.10 1.02
Ccl4 Neutrophil-derived inflammation chemoattractant −1.53 3.06
Ccl5 Neutrophil activation, increased association with infiltration 1.34 18.40
Ccr1 Involvement in neutrophil migration 1.41 −5.10
Cxcl10 Neutrophil chemotaxis, binds with Cxcr3 1.47 82.07
Cxcl11 Neutrophil chemotaxis, binds with Cxcr3 1.15 2.08
Cxcl12 Negative regulation of neutrophil chemotaxis −1.82 −3.54
Cxcl1 Neutrophil chemoattractant, binds to CXCR2 −2.53 3.26
Cxcl2 Neutrophil chemoattractant, binds to CXCR2 −3.39 9.80
Cxcl3 Neutrophil chemoattractant 1.03 6.50
Cxcl9 Associated with CXCL1 function, activated by TLR ligand 2.18 1.68
Cxcr2 Neutrophil activation, chemotaxis −1.02 −2.69
Cxcr3 Interaction with CXCL10 for chemotaxis −1.18 −38.09
Cxcr4 Negative regulation of neutrophil chemotaxis 1.11 −3.74
Cxcr7 Associated with CXCR4 −1.89 3.96
Il1b Encodes IL-1β, inflammation cytokine 1.66 5.20
Il6 Encodes IL-6, inflammation cytokine 1.30 3.86
Itgam Encodes for CD11b, migration/adhesion 1.51 −3.75
Itgb2 Encodes for CD11c, migration/adhesion 1.02 −1.72
Mapk14 Encodes for p38 MAPK, inflammation signaling −1.28 −1.93
Tnf Encodes for TNF-α, inflammation cytokine −2.34 8.54
Xcl1 Positive regulator of neutrophil chemotaxis −1.16 2.84

mRNA gene expression from male and female murine neutrophils (L6G+) stimulated with 100 ng/mL of Actinobacillus actinomycetemcomitans lipopolysaccharide, 4 h postisolation. Values represent fold change relative to the untreated control from each sex. Increased gene expression >2-fold is presented and is positive. Reduced gene expression <2-fold is presented and is negative.