Table.
Treatment vs. Control |
|||
---|---|---|---|
Gene ID | Function | Female | Male |
C5ar1 | Neutrophil migration and recruitment | 1.10 | 1.02 |
Ccl4 | Neutrophil-derived inflammation chemoattractant | −1.53 | 3.06 |
Ccl5 | Neutrophil activation, increased association with infiltration | 1.34 | 18.40 |
Ccr1 | Involvement in neutrophil migration | 1.41 | −5.10 |
Cxcl10 | Neutrophil chemotaxis, binds with Cxcr3 | 1.47 | 82.07 |
Cxcl11 | Neutrophil chemotaxis, binds with Cxcr3 | 1.15 | 2.08 |
Cxcl12 | Negative regulation of neutrophil chemotaxis | −1.82 | −3.54 |
Cxcl1 | Neutrophil chemoattractant, binds to CXCR2 | −2.53 | 3.26 |
Cxcl2 | Neutrophil chemoattractant, binds to CXCR2 | −3.39 | 9.80 |
Cxcl3 | Neutrophil chemoattractant | 1.03 | 6.50 |
Cxcl9 | Associated with CXCL1 function, activated by TLR ligand | 2.18 | 1.68 |
Cxcr2 | Neutrophil activation, chemotaxis | −1.02 | −2.69 |
Cxcr3 | Interaction with CXCL10 for chemotaxis | −1.18 | −38.09 |
Cxcr4 | Negative regulation of neutrophil chemotaxis | 1.11 | −3.74 |
Cxcr7 | Associated with CXCR4 | −1.89 | 3.96 |
Il1b | Encodes IL-1β, inflammation cytokine | 1.66 | 5.20 |
Il6 | Encodes IL-6, inflammation cytokine | 1.30 | 3.86 |
Itgam | Encodes for CD11b, migration/adhesion | 1.51 | −3.75 |
Itgb2 | Encodes for CD11c, migration/adhesion | 1.02 | −1.72 |
Mapk14 | Encodes for p38 MAPK, inflammation signaling | −1.28 | −1.93 |
Tnf | Encodes for TNF-α, inflammation cytokine | −2.34 | 8.54 |
Xcl1 | Positive regulator of neutrophil chemotaxis | −1.16 | 2.84 |
mRNA gene expression from male and female murine neutrophils (L6G+) stimulated with 100 ng/mL of Actinobacillus actinomycetemcomitans lipopolysaccharide, 4 h postisolation. Values represent fold change relative to the untreated control from each sex. Increased gene expression >2-fold is presented and is positive. Reduced gene expression <2-fold is presented and is negative.