Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 2;7(11):410. doi: 10.3390/jcm7110410

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Cyclic stretch stimulates the low-density lipoprotein receptor-related protein 6 LRP6/β-catenin signaling. (A) Cardiomyocytes analyzed by Phospho-kinase array at no stretch (control), 5%, 15%, and 25% 24 h of stretching. (B) Western blot performed to analyze the stretch-activated ion channel Piezo1 protein expression. Validation of the (C) phosphorylated-Ak transforming serine473 (AKT^S473), phosphorylated-c-Jun N-terminal kinase threonine183/tyrosine185 (JNK^T183/Y185), phosphorylated-glycogen synthase kinase-3 beta serine9 (GSK3β^S9), total AKT, JNK, and GSK3β, (D) wingless integrated (Wnt) signaling molecules LRP6, and β-catenin. Data represent at least three independent experiments in SEM ± SD. *, p value < 0.05, ***, p value < 0.001.