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. 2018 Oct 26;7(11):150. doi: 10.3390/antiox7110150

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ABT-263 reverses pulmonary artery (PA) remodeling in Sprague-Dawley rats treated with SU5416/hypoxia. Sprague-Dawley rats were treated with SU5416, subjected to sustained hypoxia for three weeks, and then maintained in normoxia for five weeks. After pulmonary vascular remodeling was developed, ABT-263 (5 mg/kg body weight) was then injected four times over a two-week period. Lung tissues were immersed in buffered 10% formalin and embedded in paraffin for haematoxylin and eosin (H&E) staining. Representative images at ×1000 and ×200 magnifications are shown. The bar graph represents means ± SEM of % PA wall thickness (n = 5). * denotes that the values were significantly different from each other at p < 0.05.