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. 2018 Nov 20;12:433. doi: 10.3389/fncel.2018.00433

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Copyright © 2018 Lively, Wong, Lam and Schlichter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kv and Kir currents in prepubertal (P21) microglia. (A) Representative whole-cell outward-rectifying Kv currents from male and female P21 microglia at 24 h in untreated cells (control) or after treatment with I+T or IL-4. For each recording, the voltage was ramped to +40 mV from a holding potential of –110 mV. (B) Summary of Kv current density (pA/pF) measured at +40 mV. Graphical summaries in (B,D) show mean ± SEM for the number of replicates indicated on each bar; and were analyzed by two-way ANOVA and Bonferroni post hoc test. ^∗∗∗p < 0.001 indicates a difference from the control current. (C) Representative inward-rectifier (Kir) currents at 24 h in untreated microglia (control) or after treatment with I+T or IL-4. From a holding potential of –110 mV, the voltage was ramped from –160 to –60 mV. (D) Summary of peak Kir inward current density (pA/pF) measured at –140 mV.