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. 2018 Nov 21;12:94. doi: 10.3389/fncir.2018.00094

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Copyright © 2018 Mulcahy, Witvliet, Holmyard, Mitchell, Chisholm, Meirovitch, Samuel and Zhen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of synapse annotation with different degrees of subjectivity. (A) Serial sections through a large, confidently annotated polyadic synapse (from IL1VL to RIPL, RMDDL and body wall muscle BWM-VL01). This synapse spans these three sections, and beyond (not shown). (B) Serial sections through a very small synapse (from RIS to RIBL and RMDR). The annotation of this synapse is less confident that the one presented in panel (A). (C) Serial sections of a membrane swelling that is confidently annotated as not-a-synapse. A small density in the membrane of RIBL with sparse vesicles is not a presynaptic specialization. (D) Serial sections through a synapse showing the occasional subjectivity involved in defining postsynaptic partners. While all annotators agreed RMGL was a postsynaptic partner of RIGL, whether SAADL should be included as a postsynaptic partner was cause for debate. White arrowheads indicate the membrane of interest. Scale bars are 500 μm.