Table 1.
Effect of permeability transition pore (PTP) modulators on CRC in CM.
| Control Ca2+ (μM) | Treatment Ca2+ (μM) | % of control | |
|---|---|---|---|
| Diamide (2 mM) | 369 ± 95 | 278 ± 80** | 75 |
| PheAsO (50 μM) | 353 ± 91 | 188 ± 61** | 53 |
| Bz-423 (100 μM) | 384 ± 159 | 199 ± 66* | 52 |
| Oligomycin (1 μM) | 380 ± 120 | 122 ± 24** | 32 |
| Mg-ADP (2 mM) | 412 ± 296 | 701 ± 258* | 170 |
| Mg-ATP (2 mM) | 260 ± 83 | 480 ± 126** | 184 |
Isolated CM were incubated in 0.25 M sucrose, 10 mM MOPS-Tris (pH 7.4), 1 mM Pi-Tris, 10 μM EGTA-Tris, 10 μM ETH129 and in the presence of different PTP modulators. Data are means ± SD of at least five independent replicates. Each treatment was compared with its relative control and analyzed by paired sample t-test (∗p < 0.05, ∗∗p < 0.01).