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. 2018 Nov 21;9:2738. doi: 10.3389/fmicb.2018.02738

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Copyright © 2018 Lata, Mishra and Banerjea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of Deubiquitinases (DUBs) in HIV-1 replication. Ubiquitin-Specific Proteases (DUBs) play an important role in viral replication. The ubiquitination and processing of Gag by ESCRT III machinery is inhibited by USP7 and USP47. A deubiquitinase DUB binds ALIX and inhibits the viral release. NEDD4-2s E3 ubiquitin ligase inhibits the action of DUB. USP7 also deubiquitinates and stabilizes HIV-1 Tat protein. In contrast, another deubiquitinase USP15 induces proteasomal degradation of HIV-1 Nef and Gag proteins.