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Orexinergic receptor subtypes OX1R and OX2R co-localized with TH in the substantia nigra. Both of the OX1R (A) and OX2R (B) were expressed in the substantia nigra region and VTA. Double-labeling immunofluorescence showed the co-localization of TH (green in A,B) and OX1R (red in A) or OXR2 (red in B) on the dopaminergic neurons in the SNpc.
