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. 2018 Nov 15;12:835. doi: 10.3389/fnins.2018.00835

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Copyright © 2018 Liu, Xue, Liu, Liu, Diao, Wang, Pan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of orexin-A on the protein expression of BDNF. (A) Immunoblot analysis showing the protein expression of BDNF in the substantia nigra and striatum of MPTP parkinsonian mice. Average protein level was quantified as ratios between BDNF and β-actin. (B) Immunoblot analysis showing the effects of orexin-A on protein expression of BDNF in the striatum after 3 days of orexin-A injection in normal mice. Average protein level was quantified as ratios between BDNF or TH and β-actin. Each value represented mean ± SEM, n = 6. ^∗∗∗P < 0.001 vs. control; ^###P < 0.001 vs. MPTP; ^ΔΔ P < 0.01, ^ΔΔΔ P < 0.001 vs. orexin-A + MPTP. SB: SB334867.