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. 2018 Nov 15;12:835. doi: 10.3389/fnins.2018.00835

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Copyright © 2018 Liu, Xue, Liu, Liu, Diao, Wang, Pan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Orexin-A increased the expression of TH and BDNF in SH-SY5Y human dopaminergic neuroblastoma cells. (A) Immunoblot analysis revealed the expression of OX1R, TH, and BDNF in SH-SY5Y cells. Original images of the blots are shown in Supplementary Figures S1–S5. (B) Protein expression of PI3K, TH, and BDNF in SH-SY5Y cells treated with orexin-A at various concentrations for 24 h. (C) Protein expression of PI3K, TH, and BDNF in SH-SY5Y cells treated with 1 nM orexin-A for different time periods. Average protein level was quantified as ratios between BDNF/TH/PI3K and β-actin. Data were presented as mean ± SEM of four independent experiments. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. control.