Table 4.
Western blots results showing the change of hepatic UPR factors at different development stages.
| Protein | IUGR/CON (E20) | IUGR/CON (3 W) | IUGR/CON (12 W) |
|---|---|---|---|
| Hspa4l | 0.128 ± 0.013/0.20 ± 0.015↓* | 0.405 ± 0.073/1.164 ± 0.309 ↓* | 0.268 ± 0.095/0.763 ± 0.148 ↓* |
| Hspa1l | NC | NC | NC |
| Creb3l3 | 1.008 ± 0.311/0.254 ± 0.051↑* | 1.666 ± 0.384/0.925 ± 0.2 ↑(p = 0.118) | NC |
| Creb3l1 | 0.077 ± 0.004/0.242 ± 0.054↓* | NC | NC |
| Mapk10 | 0.377 ± 0.044/0.675 ± 0.084↓* | NC | NC |
| eIF2α | NC | NC | NC |
| p-eIF2α | 0.553 ± 0.158/0.155 ± 0.055↑* | 0.126 ± 0.036/0.044 ± 0.0070 ↑ (p = 0.052) | 1.382 ± 0.471/0.805 ± 0.425 ↑(p = 0.14) |
| c-Jun | NC | NC | NC |
| Atf2 | 0.229 ± 0.0646/0.034 ± 0.00↑* | NC | NC |
| Atf6 | 0.173 ± 0.029/0.084 ± 0.011↑* | NC | 1.823 ± 0.415/0.591 ± 0.087↑* |
| Xbp1s | 0.27 ± 0.13/0.14 ± 0.09 ↑ (p = 0.066) | NC | NC |
| Xbp1u | NC | NC | NC |
| Grp78 | NC | NC | NC |
Data are expressed as mean ± SEM.
*
p < 0.05 vs. age-matched controls (n = 5–8).
NC, no change. ↑/↓ means increased/decreased respectively, compared with age-matched controls.