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. 2018 Nov 2;7(11):196. doi: 10.3390/cells7110196

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Values of the relationship between liver stiffness measure (continuous and categorical) and peripheral blood biomarkers (CD4⁺ Treg cells and plasma cytokines), adjusted by the main clinical and epidemiological covariables, in HIV/HCV-coinfected patients. Blue (): Values of adjusted arithmetic mean ratio (aAMR) in HIV/HCV-coinfected patients. Red (): Values of aAMR for patients with >25 kPa versus patients with <12.5 kPa (reference). Green (): Values of aAMR for patients with >25 kPa versus patients with 12.5–25 kPa (reference). Statistics. p-values were calculated by the Generalized Linear Models test with a gamma distribution (log-link). Each regression test was adjusted by age, gender, baseline CD4⁺ T cells, HIV viral load (≥50 cp/mL), high alcohol intake, diabetes, log₁₀ HCV RNA, HCV-GT1, previous IFNα HCV therapy, and prior AIDS diagnosis. Abbreviations: HCV, hepatitis C virus; HIV, human immunodeficiency virus; LSM, liver stiffness measure; aAMR, adjusted arithmetic mean ratio; CI, confidence interval; CDXX, cluster of differentiation; TGF-β1, transforming growth factor beta 1; IFN-γ, Interferon gamma; IL-XX, interleukin; Treg cells, regulatory CD4⁺ T cells; TNF-α, tumor necrosis factor alpha.

Inline graphic — Values of the relationship between liver stiffness measure (continuous and categorical) and peripheral blood biomarkers (CD4⁺ Treg cells and plasma cytokines), adjusted by the main clinical and epidemiological covariables, in HIV/HCV-coinfected patients. Blue (): Values of adjusted arithmetic mean ratio (aAMR) in HIV/HCV-coinfected patients. Red (): Values of aAMR for patients with >25 kPa versus patients with <12.5 kPa (reference). Green (): Values of aAMR for patients with >25 kPa versus patients with 12.5–25 kPa (reference). Statistics. p-values were calculated by the Generalized Linear Models test with a gamma distribution (log-link). Each regression test was adjusted by age, gender, baseline CD4⁺ T cells, HIV viral load (≥50 cp/mL), high alcohol intake, diabetes, log₁₀ HCV RNA, HCV-GT1, previous IFNα HCV therapy, and prior AIDS diagnosis. Abbreviations: HCV, hepatitis C virus; HIV, human immunodeficiency virus; LSM, liver stiffness measure; aAMR, adjusted arithmetic mean ratio; CI, confidence interval; CDXX, cluster of differentiation; TGF-β1, transforming growth factor beta 1; IFN-γ, Interferon gamma; IL-XX, interleukin; Treg cells, regulatory CD4⁺ T cells; TNF-α, tumor necrosis factor alpha.