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. 2018 Nov 9;7(11):205. doi: 10.3390/cells7110205

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Migration-induced changes in RNA stability. Altered genes upon induction of migration were detected in the presence of DRB, an RNA polymerase II inhibitor (fold change > 1.3, FDR < 0.05). Increased RNA stability is detected by up-regulation of genes in DRB-treated migrating cells compared to DRB-treated control cells, and decreased RNA stability by down-regulation. (a) A Venn diagram representing the overlap between genes with increased or decreased RNA stability levels upon induction of migration to H3K27me-dependent and independent genes. (b) Top 10 pathways of the genes with altered RNA stability levels upon induction of migration as identified by IPA.