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Synthesis of colchicine derivatives (2–12). Reagents and conditions: (a) N-bromosuccinimide (NBS), acetonitrile, room temperature; (b) MeOH/H2O, CH3SNa, room temperature; (c) 2M HCl, 90 °C, 72 h; (d) triphosgene, Et3N, respective alcohol, tetrahydrofuran (THF), 0 °C → room temperature.
