Table 6.

Linear regressions involving two independent variables (binding energy by MM/GBSA method and MlogP) of the investigated colchicine derivatives versus log IC50 (μM) in different cancer cell lines.

		MCF-7	LoVo	LoVo/DX	A549	BALB/3T3
Linear regression of colchicine derivatives (R2)	βI	0.21	0.60	0.65	0.55	0.0005
	βIIa	0.02	0.54	0.68	0.36	0.0004
	βIII	0.08	0.57	0.59	0.46	0.013
	βIVb	0.12	0.66	0.71	0.51	0.095
	βVI	0.04	0.58	0.70	0.37	0.013