Table 3.
Pathways represented among the DEG in GPO vs. CTR (Ingenuity Pathway (IPA) analysis).
| Canonical Pathways | -Log (p-Value) | Ratio | Molecules |
|---|---|---|---|
| Cholesterol Biosynthesis I | 5.76 | 0.385 | FDFT1,SQLE,NSDHL,MSMO1,SC5D |
| Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) | 5.76 | 0.385 | FDFT1,SQLE,NSDHL,MSMO1,SC5D |
| Cholesterol Biosynthesis III (via Desmosterol) | 5.76 | 0.385 | FDFT1,SQLE,NSDHL,MSMO1,SC5D |
| Superpathway of Cholesterol Biosynthesis | 5.25 | 0.222 | FDFT1,SQLE,NSDHL,IDI1,MSMO1,SC5D |
| Epoxysqualene Biosynthesis | 3.53 | 1 | FDFT1,SQLE |
| Zymosterol Biosynthesis | 2.37 | 0.333 | NSDHL,MSMO1 |
| IL-1 Signaling | 2.33 | 0.0667 | GNAI3,IL1A,PRKAR2B,MAPK8,GNA13,IRAK4 |
| PPAR Signaling | 2.26 | 0.0645 | SRA1,IL1A,PDGFA,IL1RL1,PDGFRA,PTGS2 |
| Toll-like Receptor Signaling | 2.09 | 0.0694 | UBD,IL1A,IL1RL1,MAPK8,IRAK4 |
| Role of JAK family kinases in IL-6-type Cytokine Signaling | 2.05 | 0.12 | SOCS1,MAPK8,OSM |
| NF-κB Signaling | 1.97 | 0.0462 | IL1A,BCL10,MAPK8,FCER1G,PDGFRA,TBK1,MAP3K8,IRAK4 |
| VDR/RXR Activation | 1.95 | 0.0641 | PDGFA,IL1RL1,HR,THBD,KLF4 |
| Semaphorin Signaling in Neurons | 1.94 | 0.0784 | MET,RHOB,DPYSL3,PLXNB1 |
| LXR/RXR Activation | 1.91 | 0.0545 | FDFT1,IL1A,LDLR,SREBF1,IL1RL1,PTGS2 |
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 1.88 | 0.0444 | MET,IL1A,MYH9,PDGFA,IL1RL1,PDGFRA,SMAD7,COL18A1 |
| Hepatic Cholestasis | 1.78 | 0.0461 | IL1A,PRKAR2B,SREBF1,IL1RL1,MAPK8,OSM,IRAK4 |
| IL-8 Signaling | 1.75 | 0.0421 | GNAI3,MTOR,RHOB,MAPK8,PTGS2,GNA13,IRAK4,MYL12B |
| Nucleotide Excision Repair Pathway | 1.72 | 0.0909 | ERCC4,XPC,POLR2J |