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. 2018 Oct 26;7(11):390. doi: 10.3390/jcm7110390

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Osteopontin (SPP1) is overexpressed in colorectal liver metastases. (a) Osteopontin (SPP1) mRNA expression levels are strongly elevated in colorectal cancer (CRC) tumour samples compared to normal colon tissue samples (u-test, p (***) < 0.001); (b) SPP1 mRNA expression levels are significantly elevated in colorectal liver metastases (CRLM) tissue samples compared to normal liver tissue (u-test, p (**) < 0.01); (c) Immunohistochemical osteopontin staining in three exemplary CRLM samples (left, middle and right column). Left column: osteopontin is highly expressed in CRLM compared to normal liver tissue; middle and right column: tumour cells show a strong osteopontin expression (black arrow heads) while the peritumoral stromal tissue displays a weak osteopontin signal (black arrows); (upper panel: 100-fold magnification, middle panel: 200-fold magnification, lower panel: 400-fold magnification).