Figure 3.

Elevated preoperative levels of circulating osteopontin are associated with a reduced overall survival after resection of colorectal liver metastases. (a) Patients with high preoperative osteopontin concentrations (>75th percentile) show a significantly impaired overall survival (OS) compared to patients with low osteopontin levels (log-rank test, p = 0.008); (b) Patients with initial osteopontin serum above our established ideal cut-off value (264.4 ng/mL) show a strikingly reduced median OS of 304 days compared to 1394 days for patients with osteopontin serum levels below this cut-off (log-rank test, p = 0.003).