Figure 1.

Regulation of the expression and activity of 2-Cys peroxiredoxins (Prxs). Prx I expression is mainly regulated by nuclear factor (erythroid-derived 2)-like 2 (Nrf2), whereas Prx II through V are regulated by promoter methylation. Note that hyper-methylation on the Prx I promoter has been reported in oligodendroglial tumors. To date, four compounds (conoidin A, adenanthin, AMRI59, and JDA-202) have been validated for inhibiting Prx I and/or Prx II in vitro and in vivo. As 2-Cys Prxs suppress the apoptosis of cancer cells, chemical inhibitors against 2-Cys Prxs are most likely to induce apoptosis in cancer cells. CpG: cytosine-guanine site.