Scheme 1.
Synthesis of colchicine derivatives (2–8). Reagents and conditions: (a) for 3, NCS, acetonitrile, RT; (b) for 5, NBS, acetonitrile, RT; (c) for 7, NIS, AcOH, 70 °C; (d) MeOH/H2O, CH3SNa, RT.
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