Table A2.

The associations between fatty liver index (FLI) and the development of gallstones (n = 194,666).

	Number	Person-Years	Incident Case	Incidence Density (1000 Person-Year)	Age- and Sex-Adjusted HR a (95% CI)	Multivariate HR a (95% CI)
						Model 1	Model 2
Total
FLI <30	142,201	686,999.9	2197	3.2	1.00 (reference)	1.00 (reference)	1.00 (reference)
FLI 30–<60	34,267	173,595.0	876	5.0	1.70 (1.55–1.85)	1.31 (1.17–1.46)	1.22 (1.08–1.38)
FLI ≥60	18,198	89,353.3	572	6.4	2.25 (2.03–2.49)	1.47 (1.27–1.71)	1.29 (1.08–1.54)
p for trend					<0.001	<0.001	0.002
Men
FLI <30	52,982	272,555.5	795	2.9	1.00 (reference)	1.00 (reference)	1.00 (reference)
FLI 30–<60	29,360	152,751.1	712	4.7	1.51 (1.36–1.67)	1.29 (1.13–1.48)	1.21 (1.05–1.41)
FLI ≥60	16,556	82,794.1	491	5.9	1.98 (1.77–2.21)	1.52 (1.27–1.82)	1.30 (1.04–1.63)
p for trend					<0.001	<0.001	0.013
Women
FLI <30	89,219	414,444.4	1402	3.3	1.00 (reference)	1.00 (reference)	1.00 (reference)
FLI 30–<60	4907	20,843.9	164	7.8	2.36 (2.00–2.79)	1.38 (1.11–1.71)	1.24 (0.98–1.56)
FLI ≥60	1642	6559.2	81	12.3	3.83 (3.05–4.81)	1.46 (1.05–2.04)	1.31 (0.91–1.89)
p for trend					<0.001	0.004	0.074

^a estimated from parametric proportional hazard model. The p-value for the interaction of sex and FLI on the risk of incident gallstone was 0.503. Multivariable adjusted model 1 was adjusted for age, sex, BMI, center, year of examination, education level, smoking, alcohol intake, exercise, total calorie intake, history of hypertension, history of diabetes and medication for dyslipidemia, except sex in the stratified analysis by sex; model 2: model 1 plus adjusted for LDL-C, HDL-C, triglycerides, HOMA-IR, or hsCRP. Abbreviations: CI, confidence intervals; FLI, fatty liver index; HDL-C, high-density lipoprotein-cholesterol; HR, hazard ratios; hsCRP, high sensitivity C-reactive protein; HOMA-IR, homeostasis model assessment of insulin resistance; LDL-C, low-density lipoprotein cholesterol; NAFLD, nonalcoholic fatty liver disease.