Table 5.
Comparison of sensitivity and specificity of previously published panels with values obtained.
| Panels | Sensitivity (%) | Specificity (%) | Specimen Type | Methods | References |
|---|---|---|---|---|---|
| HIC-1/RARβ2/RASSF1A | 90 | 100 | Plasma | MSP a | [60] |
| APC/GSTP1/RARβ2/RASSF1A | 62 | 87 | Plasma | QMSP b | [55] |
| ATM/RASSF1A | 36 | 100 | Plasma | QMSP b | [58] |
|
RARβ2/RASSF1A/SCGB3A1/
Twist |
98.3 | 81.6 | Serum | Two-steps QMSP b | [54] |
| ITIH5/DKK3/RASSF1A | 67 | 72 | Serum | QMSP b | [25] |
| CDH1/RASSF1A | 76 | 90 | Serum | MSP a | [57] |
| SFN/P16/hMLH1/HOXD13/PCDHGB7/RASSF1A | 79.6 | 72.4 | Serum | QMSP b | [59] |
| ESR1/14-3-3-σ | 81 | 55 | Serum | QMSP b | [56] |
| GSTP1/RARβ2/RASSF1A | 22 | 93 | Serum | One-step MSP a | [62] |
| DAPK1/RASSF1A | 96 | 71 | Serum | MSP a | [63] |
| APC/ESR1/RASSF1A | 53 | 84 | Serum | QMSP b | [61] |
| APC/FOXA1/RASSF1A | 81.82 | 76.92 | Plasma | Multiplex QMSP b | --- |
a MSP—Methylation-Specific Polimerase Chain Reaction; b QMSP—Quantitative Methylation-Specific Polimerase Chain Reaction.