Figure 5.

Graded COI causes dose-dependent severities of TON. (a) Averaged pSTRs of traumatized eyes (right eyes), at seven measured intensities, in the two groups of TON with velocities of 2.0 m/s (pink traces) and 3.0 m/s (green traces) superimposed over the corresponding responses obtained from right eyes in the naïve control group (black traces). (b) Dose-dependent decreases in amplitudes of pSTR with increased impactor's velocity. (c) Analysis of nSTR amplitudes did not show a dose-dependent relationship with the impactor velocity despite these amplitudes appearing to be significantly reduced in TON groups over the flash range of (5 × 10⁻⁸ to 9 × 10⁻⁸) in comparison with the naïve control group, n = 3–4/group. (d–f) Averaged STRs of contralateral eyes (left eyes), at seven measured intensities, from the two groups of TON with velocities of 2.0 m/s (dashed pink traces) and 3.0 m/s (dashed green traces) were superimposed over the corresponding responses obtained from left eyes in the naïve control group (dashed black traces). Analysis of pSTRs (e) as well as nSTRs (f) did not show a statistically significant effect of the impactor on inner retinal functionality of contralateral eyes in TON studied groups. n = 3–4/group.